Cerebrospinal fluid complement system biomarkers in demyelinating disease
نویسندگان
چکیده
منابع مشابه
Cerebrospinal Fluid Biomarkers for Huntington's Disease.
Cerebrospinal fluid (CSF) is enriched in brain-derived components and represents an accessible and appealing means of interrogating the CNS milieu to study neurodegenerative diseases and identify biomarkers to facilitate the development of novel therapeutics. Many such CSF biomarkers have been proposed for Huntington's disease (HD) but none has been validated for clinical trial use. Across many...
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Down syndrome (DS), present in nearly six million people, is associated with an extremely high risk to develop Alzheimer's disease (AD). Amyloid-β and tau pathology are omnipresent from age 40 years onward, but clinical symptoms do not appear in all DS individuals. Dementia diagnostics is complex in this population, illustrating the great need for predictive biomarkers. Although blood biomarker...
متن کاملCerebrospinal fluid biomarkers in the evaluation of Alzheimer disease.
Alzheimer disease (AD), the most prevalent form of dementia in older adults, is a neurodegenerative disorder characterized by cerebral amyloid angiopathy, extracellular accumulation of amyloid -protein (A ) in senile plaques, and intracellular accumulation of hyperphosphorylated proteins in neurofibrillary tangles in cortical and limbic brain regions. As life expectancy increases, the number of...
متن کاملAlzheimer’s Disease: Biomarkers in the Genome, Blood, and Cerebrospinal Fluid
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that slowly destroys memory and thinking skills, resulting in behavioral changes. It is estimated that nearly 36 million are affected globally with numbers reaching 115 million by 2050. AD can only be definitively diagnosed at autopsy since its manifestations of senile plaques and neurofibrillary tangles throughout the brain c...
متن کاملCerebrospinal Fluid Inflammatory Biomarkers Reflect Clinical Severity in Huntington’s Disease
INTRODUCTION Immune system activation is involved in Huntington's disease (HD) pathogenesis and biomarkers for this process could be relevant to study the disease and characterise the therapeutic response to specific interventions. We aimed to study inflammatory cytokines and microglial markers in the CSF of HD patients. METHODS CSF TNF-α, IL-1β, IL-6, IL-8, YKL-40, chitotriosidase, total tau...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal
سال: 2019
ISSN: 1352-4585,1477-0970
DOI: 10.1177/1352458519887905